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FOXO4 (Forkhead box protein O4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Transcription factor involved in the regulation of the insulin signalling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.96, genetic association 0.00, somatic mutation 0.89).
In plain words · FOXO4 (Forkhead box protein O4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
FOXO4 (Forkhead box protein O4) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Transcription factor involved in the regulation of the insulin signalling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1.
No product in this corpus aims at FOXO4 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1997. Earliest sequence paper UniProt cites for the protein: Peters et al, Hum. Genet, 1997, "AFX1 and p54nrb: fine mapping, genomic structure, and exclusion as candidate genes of X-linked dystonia parkinsonism". Source.
Sources: HGNC HGNC:7139 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P98177 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000184481 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Transcription factor involved in the regulation of the insulin signalling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity. Location: Cytoplasm; Nucleus (UniProt). Locus Xq13.1 (HGNC).
Query for this target: (TITLE:"FOXO4" OR ABSTRACT:"FOXO4" OR TITLE:"forkhead box O4" OR ABSTRACT:"forkhead box O4" OR TITLE:"Forkhead box protein O4" OR ABSTRACT:"Forkhead box protein O4" OR TITLE:"AFX1" OR ABSTRACT:"AFX1" OR TITLE:"MLLT7" OR ABSTRACT:"MLLT7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXO4, not a curated reading list.