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FOXL2 (Forkhead box protein L2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9.
CIViC holds 4 clinical evidence items and 0 assertions across 1 variant. IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Ovarian Epithelial Tumour.
In plain words · FOXL2 (Forkhead box protein L2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
FOXL2 (Forkhead box protein L2) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination.
No product in this corpus aims at FOXL2 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
Tumour-specific alteration: the catalogues call it an oncogene driver (IntOGen cohort analysis finds it activated more often than chance); what a medicine would aim at or exploit is the altered form or its loss, absent from normal cells; no corpus medicine is aimed at it yet. HPA FOXL2: RNA tissue enhanced (cervix 14 nTPM, fallopian tube 13 nTPM, ovary 43 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Ovarian cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 6 of scripts/fetch-target-specificity.ts.)
Sources: UniProt P58012; CIViC gene FOXL2; IntOGen FOXL2; Human Protein Atlas FOXL2 tissue; Open Targets ENSG00000183770 associations
First described 2001. Earliest sequence paper UniProt cites for the protein: Crisponi et al, Nat. Genet, 2001, "The putative forkhead transcription factor FOXL2 is mutated in blepharophimosis/ptosis/epicanthus inversus syndrome". Source.
Sources: HGNC HGNC:1092 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P58012 (protein name, function text, keywords and locations (REST API)); CIViC gene FOXL2 (4 evidence items, 0 assertions, 1 variants; diseases: Granulosa Cell Tumour, Ovarian Sex-cord Stromal Tumour, Adult-type Granulosa Cell Tumour Of The Ovary (GraphQL API, CC0)); IntOGen FOXL2 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Transcriptional regulator. Critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. Prevents trans-differentiation of ovary to testis through transcriptional repression of the Sertoli cell-promoting gene SOX9. Has apoptotic activity in ovarian cells. Suppresses ESR1-mediated transcription of PTGS2/COX2 stimulated by tamoxifen. Is a regulator of CYP19 expression. Location: Nucleus (UniProt). Locus 3q22.3 (HGNC).
RNA: tissue enhanced (cervix 14 nTPM, fallopian tube 13 nTPM, ovary 43 nTPM), detected in some normal tissues.
No normal tissue stained high; medium in Endometrium, Ovary.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FOXL2" OR ABSTRACT:"FOXL2" OR TITLE:"forkhead box L2" OR ABSTRACT:"forkhead box L2" OR TITLE:"Forkhead box protein L2" OR ABSTRACT:"Forkhead box protein L2" OR TITLE:"BPES1" OR ABSTRACT:"BPES1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXL2, not a curated reading list.