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FOXF1 (Forkhead box protein F1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Probable transcription activator for a number of lung-specific genes.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Bevacizumab.
In plain words · FOXF1 (Forkhead box protein F1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
FOXF1 (Forkhead box protein F1) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Probable transcription activator for a number of lung-specific genes. Location: Nucleus (UniProt).
No product in this corpus aims at FOXF1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA FOXF1: RNA tissue enhanced (intestine 58 nTPM, urinary bladder 48 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas FOXF1 tissue; Open Targets ENSG00000103241 associations
First described 1994. Earliest sequence paper UniProt cites for the protein: Pierrou et al, EMBO J, 1994, "Cloning and characterization of seven human forkhead proteins: binding site specificity and DNA bending". Source.
Sources: HGNC HGNC:3809 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q12946 (protein name, function text, keywords and locations (REST API)); CIViC gene FOXF1 (1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0))
Probable transcription activator for a number of lung-specific genes. Location: Nucleus (UniProt). Locus 16q24.1 (HGNC).
RNA: tissue enhanced (intestine 58 nTPM, urinary bladder 48 nTPM), detected in many normal tissues.
No normal tissue stained high.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FOXF1" OR ABSTRACT:"FOXF1" OR TITLE:"forkhead box F1" OR ABSTRACT:"forkhead box F1" OR TITLE:"Forkhead box protein F1" OR ABSTRACT:"Forkhead box protein F1" OR TITLE:"FREAC1" OR ABSTRACT:"FREAC1" OR TITLE:"FKHL5" OR ABSTRACT:"FKHL5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXF1, not a curated reading list.