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FOXC2 (Forkhead box protein C2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Transcriptional activator.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant, naming Oxaliplatin.
In plain words · FOXC2 (Forkhead box protein C2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
FOXC2 (Forkhead box protein C2) is a protein that switches other genes on and off. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer.
Transcriptional activator. Location: Nucleus (UniProt).
No product in this corpus aims at FOXC2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA FOXC2: RNA tissue enriched (blood vessel 37 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Colorectal cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas FOXC2 tissue; Open Targets ENSG00000176692 associations
First described 1997. Earliest sequence paper UniProt cites for the protein: Miura et al, Genomics, 1997, "Isolation of the mouse (MFH-1) and human (FKHL 14) mesenchyme fork head-1 genes reveals conservation of their gene and protein structures". Source.
Sources: HGNC HGNC:3801 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99958 (protein name, function text, keywords and locations (REST API)); CIViC gene FOXC2 (1 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer (GraphQL API, CC0))
Transcriptional activator. Location: Nucleus (UniProt). Locus 16q24.1 (HGNC).
RNA: tissue enriched (blood vessel 37 nTPM), detected in many normal tissues.
No normal tissue stained high.
RNA cancer enhanced: Kidney Renal Clear Cell Carcinoma 8 pTPM.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FOXC2" OR ABSTRACT:"FOXC2" OR TITLE:"forkhead box C2" OR ABSTRACT:"forkhead box C2" OR TITLE:"Forkhead box protein C2" OR ABSTRACT:"Forkhead box protein C2" OR TITLE:"MFH-1" OR ABSTRACT:"MFH-1" OR TITLE:"FKHL14" OR ABSTRACT:"FKHL14") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOXC2, not a curated reading list.