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FOSB (FosB proto-oncogene, AP-1 transcription factor subunit) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Heterodimerises with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity. As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin. Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signalling pathway.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · FOSB (FosB proto-oncogene, AP-1 transcription factor subunit) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
FOSB (FosB proto-oncogene, AP-1 transcription factor subunit) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Heterodimerises with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity.
No product in this corpus aims at FOSB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA FOSB: RNA low tissue specificity; high antibody staining in 2 normal tissues; highest cancer staining melanoma (1 of 11 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas FOSB tissue; Open Targets ENSG00000125740 associations
First described 1992. Earliest sequence paper UniProt cites for the protein: Martin-Gallardo et al, Nat. Genet, 1992, "Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3". Source.
Sources: HGNC HGNC:3797 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P53539 (protein name, function text, keywords and locations (REST API)); CIViC gene FOSB (1 evidence items, 0 assertions, 1 variants; diseases: Osteoblastoma (GraphQL API, CC0))
Heterodimerises with proteins of the JUN family to form an AP-1 transcription factor complex, thereby enhancing their DNA binding activity to gene promoters containing an AP-1 consensus sequence 5'-TGA[GC]TCA-3' and enhancing their transcriptional activity. As part of the AP-1 complex, facilitates enhancer selection together with cell-type-specific transcription factors by collaboratively binding to nucleosomal enhancers and recruiting the SWI/SNF (BAF) chromatin remodeling complex to establish accessible chromatin. Together with JUN, plays a role in activation-induced cell death of T cells by binding to the AP-1 promoter site of FASLG/CD95L, and inducing its transcription in response to activation of the TCR/CD3 signalling pathway. Exhibits transactivation activity in vitro. Involved in the display of nurturing behaviour towards newborns. May play a role in neurogenesis in the hippocampus and in learning and memory-related tasks by regulating the expression of various genes involved in neurogenesis, depression and epilepsy. Location: Nucleus (UniProt). Locus 19q13.32 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adipose tissue, Lymph node, Ovary, Salivary gland, Spleen, Thyroid gland, Tonsil.
Medium only: breast cancer, cervical cancer, liver cancer, pancreatic cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FOSB" OR ABSTRACT:"FOSB" OR TITLE:"FosB proto-oncogene, AP-1 transcription factor subunit" OR ABSTRACT:"FosB proto-oncogene, AP-1 transcription factor subunit" OR TITLE:"G0S3" OR ABSTRACT:"G0S3" OR TITLE:"GOS3" OR ABSTRACT:"GOS3" OR TITLE:"AP-1" OR ABSTRACT:"AP-1" OR TITLE:"MGC42291" OR ABSTRACT:"MGC42291") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FOSB, not a curated reading list.