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FMN2 (Formin-2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a DNA repair gene, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
Actin-binding protein that is involved in actin cytoskeleton assembly and reorganisation. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibres, providing a novel link between actin cytoskeleton dynamics and intracellular transport.
Open Targets scores its association with cancer at 0.52 (direct and indirect evidence; datatypes literature 0.72, genetic association 0.57, somatic mutation 0.52). IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Pancreatic Adenocarcinoma.
In plain words · FMN2 (Formin-2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a DNA repair gene, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
FMN2 (Formin-2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor and a DNA repair gene, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Pancreatic ductal adenocarcinoma.
Actin-binding protein that is involved in actin cytoskeleton assembly and reorganisation. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2.
No product in this corpus aims at FMN2 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2000. Earliest sequence paper UniProt cites for the protein: Leader et al, Mech. Dev, 2000, "Formin-2, a novel formin homology protein of the cappuccino subfamily, is highly expressed in the developing and adult central nervous system". Source.
Sources: HGNC HGNC:14074 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NZ56 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000155816 (association with cancer (MONDO_0004992) 0.52; (GraphQL API, CC0)); IntOGen FMN2 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Actin-binding protein that is involved in actin cytoskeleton assembly and reorganisation. Acts as an actin nucleation factor and promotes assembly of actin filaments together with SPIRE1 and SPIRE2. Involved in intracellular vesicle transport along actin fibres, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning, asymmetric oocyte division and polar body extrusion during female germ cell meiosis. Plays a role in responses to DNA damage, cellular stress and hypoxia by protecting CDKN1A against degradation, and thereby plays a role in stress-induced cell cycle arrest. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. Location: Cytoplasm, cytoskeleton; Cytoplasm, cytosol; Cytoplasm, perinuclear region; Nucleus (UniProt). Locus 1q43 (HGNC).
Query for this target: (TITLE:"FMN2" OR ABSTRACT:"FMN2" OR TITLE:"formin 2" OR ABSTRACT:"formin 2" OR TITLE:"Formin-2" OR ABSTRACT:"Formin-2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FMN2, not a curated reading list.