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FMN1 (Formin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays a role in the formation of adherens junction and the polymerisation of linear actin cables.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.42, animal model 0.65, genetic association 0.81).
In plain words · FMN1 (Formin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
FMN1 (Formin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays a role in the formation of adherens junction and the polymerisation of linear actin cables. Location: Nucleus; Cytoplasm; Cell junction, adherens junction; Cell membrane (UniProt).
No product in this corpus aims at FMN1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:3768 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q68DA7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000248905 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0))
Plays a role in the formation of adherens junction and the polymerisation of linear actin cables. Location: Nucleus; Cytoplasm; Cell junction, adherens junction; Cell membrane (UniProt). Locus 15q13.3 (HGNC).
Query for this target: (TITLE:"FMN1" OR ABSTRACT:"FMN1" OR TITLE:"formin 1" OR ABSTRACT:"formin 1" OR TITLE:"Formin-1" OR ABSTRACT:"Formin-1" OR TITLE:"DKFZP686C2281" OR ABSTRACT:"DKFZP686C2281" OR TITLE:"FLJ45135" OR ABSTRACT:"FLJ45135" OR TITLE:"MGC125288" OR ABSTRACT:"MGC125288") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FMN1, not a curated reading list.