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FIP1L1 (Pre-mRNA 3'-end-processing factor FIP1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognising the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site.
Open Targets scores its association with cancer at 0.55 (direct and indirect evidence; datatypes literature 0.70, affected pathway 0.76, genetic association 0.09, somatic mutation 0.50).
In plain words · FIP1L1 (Pre-mRNA 3'-end-processing factor FIP1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
FIP1L1 (Pre-mRNA 3'-end-processing factor FIP1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognising the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition.
No product in this corpus aims at FIP1L1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2001. Earliest sequence paper UniProt cites for the protein: Wiemann et al, Genome Res, 2001, "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Source.
Sources: HGNC HGNC:19124 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6UN15 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000145216 (association with cancer (MONDO_0004992) 0.55; (GraphQL API, CC0))
Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognising the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. FIP1L1 contributes to poly(A) site recognition and stimulates poly(A) addition. Binds to U-rich RNA sequence elements surrounding the poly(A) site. May act to tether poly(A) polymerase to the CPSF complex. Location: Nucleus (UniProt). Locus 4q12 (HGNC).
Query for this target: (TITLE:"FIP1L1" OR ABSTRACT:"FIP1L1" OR TITLE:"factor interacting with PAPOLA and CPSF1" OR ABSTRACT:"factor interacting with PAPOLA and CPSF1" OR TITLE:"Pre-mRNA 3'-end-processing factor FIP1" OR ABSTRACT:"Pre-mRNA 3'-end-processing factor FIP1" OR TITLE:"DKFZp586K0717" OR ABSTRACT:"DKFZp586K0717" OR TITLE:"FIP1" OR ABSTRACT:"FIP1" OR TITLE:"hFip1" OR ABSTRACT:"hFip1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FIP1L1, not a curated reading list.