Loading
FGG (Fibrinogen gamma chain) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerises to form an insoluble fibrin matrix. Has a major function in haemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilise the lesion and guide cell migration during re-epithelialisation.
Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes clinical 0.43, affected pathway 0.97, literature 0.84, genetic association 0.24, animal model 0.38).
In plain words · FGG (Fibrinogen gamma chain) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
FGG (Fibrinogen gamma chain) is a gene. The public catalogues list it as a drug target, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerises to form an insoluble fibrin matrix. Has a major function in haemostasis as one of the primary components of blood clots.
No product in this corpus aims at FGG yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role drug-target; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA FGG: RNA tissue enriched (liver 15,475 nTPM); high antibody staining in 1 normal tissue. Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas FGG tissue; Open Targets ENSG00000171557 associations
First described 1980. Earliest sequence paper UniProt cites for the protein: Henschen et al, 1980, "Human fibrinogen: sequence, sulfur bridges, glycosylation and some structural variants". Source.
Sources: HGNC HGNC:3694 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P02679 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000171557 (association with cancer (MONDO_0004992) 0.68; (GraphQL API, CC0))
Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerises to form an insoluble fibrin matrix. Has a major function in haemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilise the lesion and guide cell migration during re-epithelialisation. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Location: Secreted (UniProt). Locus 4q32.1 (HGNC).
RNA: tissue enriched (liver 15,475 nTPM), detected in many normal tissues.
RNA cancer enriched: Liver Hepatocellular Carcinoma 4,056 pTPM.
No cancer stained high; medium in colorectal cancer, liver cancer, lung cancer, renal cancer.
HPA FGG tissue · HPA FGG pathology · HPA protein class: FDA approved drug targets
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FGG" OR ABSTRACT:"FGG" OR TITLE:"fibrinogen gamma chain" OR ABSTRACT:"fibrinogen gamma chain" OR TITLE:"Fibrinogen gamma chain" OR ABSTRACT:"Fibrinogen gamma chain") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGG, not a curated reading list.