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FGF8 (Fibroblast growth factor 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.92, affected pathway 0.98, animal model 0.30, genetic association 0.00).
In plain words · FGF8 (Fibroblast growth factor 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
FGF8 (Fibroblast growth factor 8) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis.
No product in this corpus aims at FGF8 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1995. Earliest sequence paper UniProt cites for the protein: Tanaka et al, FEBS Lett, 1995, "Human androgen-induced growth factor in prostate and breast cancer cells: its molecular cloning and growth properties". Source.
Sources: HGNC HGNC:3686 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P55075 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000107831 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0))
Plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. Required for normal brain, eye, ear and limb development during embryogenesis. Required for normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Plays a role in neurite outgrowth in hippocampal cells. Location: Secreted (UniProt). Locus 10q24.32 (HGNC).
Query for this target: (TITLE:"FGF8" OR ABSTRACT:"FGF8" OR TITLE:"fibroblast growth factor 8" OR ABSTRACT:"fibroblast growth factor 8" OR TITLE:"Fibroblast growth factor 8" OR ABSTRACT:"Fibroblast growth factor 8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF8, not a curated reading list.