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FGF5 (Fibroblast growth factor 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.91, affected pathway 0.98, animal model 0.59, genetic association 0.00).
In plain words · FGF5 (Fibroblast growth factor 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
FGF5 (Fibroblast growth factor 5) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle.
No product in this corpus aims at FGF5 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1988. Earliest sequence paper UniProt cites for the protein: Zhan et al, Mol. Cell. Biol, 1988, "The human FGF-5 oncogene encodes a novel protein related to fibroblast growth factors". Source.
Sources: HGNC HGNC:3683 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P12034 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000138675 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0))
Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase. Location: Secreted (UniProt). Locus 4q21.21 (HGNC).
Query for this target: (TITLE:"FGF5" OR ABSTRACT:"FGF5" OR TITLE:"fibroblast growth factor 5" OR ABSTRACT:"fibroblast growth factor 5" OR TITLE:"Fibroblast growth factor 5" OR ABSTRACT:"Fibroblast growth factor 5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF5, not a curated reading list.