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FGF22 (Fibroblast growth factor 22) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development.
Open Targets scores its association with cancer at 0.60 (direct and indirect evidence; datatypes literature 0.36, affected pathway 0.97, genetic association 0.00).
In plain words · FGF22 (Fibroblast growth factor 22) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
FGF22 (Fibroblast growth factor 22) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro).
No product in this corpus aims at FGF22 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2001. Earliest sequence paper UniProt cites for the protein: Nakatake et al, Biochim. Biophys. Acta, 2001, "Identification of a novel fibroblast growth factor, FGF-22, preferentially expressed in the inner root sheath of the hair follicle". Source.
Sources: HGNC HGNC:3679 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HCT0 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000070388 (association with cancer (MONDO_0004992) 0.60; (GraphQL API, CC0))
Plays a role in the fasting response, glucose homeostasis, lipolysis and lipogenesis. Can stimulate cell proliferation (in vitro). May be involved in hair development. Location: Secreted (UniProt). Locus 19p13.3 (HGNC).
Query for this target: (TITLE:"FGF22" OR ABSTRACT:"FGF22" OR TITLE:"fibroblast growth factor 22" OR ABSTRACT:"fibroblast growth factor 22" OR TITLE:"Fibroblast growth factor 22" OR ABSTRACT:"Fibroblast growth factor 22") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF22, not a curated reading list.