Loading
FGF18 (Fibroblast growth factor 18) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.89, affected pathway 0.98, animal model 0.51, genetic association 0.00).
In plain words · FGF18 (Fibroblast growth factor 18) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
FGF18 (Fibroblast growth factor 18) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development.
No product in this corpus aims at FGF18 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Hu M.C.-T. et al, Mol. Cell. Biol, 1998, "FGF-18, a novel member of the fibroblast growth factor family, stimulates hepatic and intestinal proliferation". Source.
Sources: HGNC HGNC:3674 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O76093 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156427 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0))
Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation. Location: Secreted (UniProt). Locus 5q35.1 (HGNC).
Query for this target: (TITLE:"FGF18" OR ABSTRACT:"FGF18" OR TITLE:"fibroblast growth factor 18" OR ABSTRACT:"fibroblast growth factor 18" OR TITLE:"Fibroblast growth factor 18" OR ABSTRACT:"Fibroblast growth factor 18" OR TITLE:"FGF-18" OR ABSTRACT:"FGF-18" OR TITLE:"ZFGF5" OR ABSTRACT:"ZFGF5") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF18, not a curated reading list.