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FGF17 (Fibroblast growth factor 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays an important role in the regulation of embryonic development and as signalling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.74, affected pathway 0.98, genetic association 0.00).
In plain words · FGF17 (Fibroblast growth factor 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
FGF17 (Fibroblast growth factor 17) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays an important role in the regulation of embryonic development and as signalling molecule in the induction and patterning of the embryonic brain. Required for normal brain development.
No product in this corpus aims at FGF17 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Hoshikawa et al, Biochem. Biophys. Res. Commun, 1998, "Structure and expression of a novel fibroblast growth factor, FGF-17, preferentially expressed in the embryonic brain". Source.
Sources: HGNC HGNC:3673 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O60258 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000158815 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Plays an important role in the regulation of embryonic development and as signalling molecule in the induction and patterning of the embryonic brain. Required for normal brain development. Location: Secreted (UniProt). Locus 8p21.3 (HGNC).
Query for this target: (TITLE:"FGF17" OR ABSTRACT:"FGF17" OR TITLE:"fibroblast growth factor 17" OR ABSTRACT:"fibroblast growth factor 17" OR TITLE:"Fibroblast growth factor 17" OR ABSTRACT:"Fibroblast growth factor 17" OR TITLE:"FGF-13" OR ABSTRACT:"FGF-13") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF17, not a curated reading list.