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FGF16 (Fibroblast growth factor 16) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.86, affected pathway 0.98).
In plain words · FGF16 (Fibroblast growth factor 16) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
FGF16 (Fibroblast growth factor 16) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Location: Secreted (UniProt).
No product in this corpus aims at FGF16 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1998. Earliest sequence paper UniProt cites for the protein: Miyake et al, Biochem. Biophys. Res. Commun, 1998, "Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family". Source.
Sources: HGNC HGNC:3672 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O43320 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000196468 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Plays an important role in the regulation of embryonic development, cell proliferation and cell differentiation, and is required for normal cardiomyocyte proliferation and heart development. Location: Secreted (UniProt). Locus Xq21.1 (HGNC).
Query for this target: (TITLE:"FGF16" OR ABSTRACT:"FGF16" OR TITLE:"fibroblast growth factor 16" OR ABSTRACT:"fibroblast growth factor 16" OR TITLE:"Fibroblast growth factor 16" OR ABSTRACT:"Fibroblast growth factor 16" OR TITLE:"MF4" OR ABSTRACT:"MF4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF16, not a curated reading list.