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FGF13 (Fibroblast growth factor 13) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Microtubule-binding protein which directly binds tubulin and is involved in both polymerisation and stabilisation of microtubules. Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarisation and migration in the cerebral cortex and the hippocampus.
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · FGF13 (Fibroblast growth factor 13) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
FGF13 (Fibroblast growth factor 13) is a gene. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Prostate cancer.
Microtubule-binding protein which directly binds tubulin and is involved in both polymerisation and stabilisation of microtubules.
No product in this corpus aims at FGF13 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA FGF13: RNA tissue enhanced (brain 65 nTPM, skeletal muscle 52 nTPM, tongue 41 nTPM); blood lineage lineage enriched (granulocytes 3 nTPM); no normal tissue stained high. Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Prostate cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas FGF13 tissue; Open Targets ENSG00000129682 associations
First described 1996. Earliest sequence paper UniProt cites for the protein: Smallwood P.M. et al, Proc. Natl. Acad. Sci. U.S.A, 1996, "Fibroblast growth factor (FGF) homologous factors: new members of the FGF family implicated in nervous system development". Source.
Sources: HGNC HGNC:3670 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q92913 (protein name, function text, keywords and locations (REST API)); CIViC gene FGF13 (1 evidence items, 0 assertions, 1 variants; diseases: Prostate Cancer (GraphQL API, CC0))
Microtubule-binding protein which directly binds tubulin and is involved in both polymerisation and stabilisation of microtubules. Through its action on microtubules, may participate in the refinement of axons by negatively regulating axonal and leading processes branching. Plays a crucial role in neuron polarisation and migration in the cerebral cortex and the hippocampus. Regulates voltage-gated sodium channel transport and function. May also play a role in MAPK signalling. Required for the development of axonal initial segment-targeting inhibitory GABAergic synapses made by chandelier neurons. Location: Nucleus; Cytoplasm; Cell projection, filopodium; Cell projection, growth cone (UniProt). Locus Xq26.3-q27.1 (HGNC).
RNA: tissue enhanced (brain 65 nTPM, skeletal muscle 52 nTPM, tongue 41 nTPM), detected in all normal tissues. Blood: lineage enriched (granulocytes 3 nTPM).
No normal tissue stained high.
RNA cancer enhanced: Prostate Adenocarcinoma 35 pTPM.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FGF13" OR ABSTRACT:"FGF13" OR TITLE:"fibroblast growth factor 13" OR ABSTRACT:"fibroblast growth factor 13" OR TITLE:"Fibroblast growth factor 13" OR ABSTRACT:"Fibroblast growth factor 13" OR TITLE:"FHF2" OR ABSTRACT:"FHF2" OR TITLE:"FGF2" OR ABSTRACT:"FGF2" OR TITLE:"FLJ30672" OR ABSTRACT:"FLJ30672") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGF13, not a curated reading list.