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FGD5 (FYVE, RhoGEF and PH domain-containing protein 5) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation.
IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Acute Myeloid Leukaemia.
In plain words · FGD5 (FYVE, RhoGEF and PH domain-containing protein 5) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
FGD5 (FYVE, RhoGEF and PH domain-containing protein 5) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia.
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation.
No product in this corpus aims at FGD5 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 2000. Earliest sequence paper UniProt cites for the protein: Dias Neto et al, Proc. Natl. Acad. Sci. U.S.A, 2000, "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Source.
Sources: HGNC HGNC:19117 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6ZNL6 (protein name, function text, keywords and locations (REST API)); IntOGen FGD5 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. Location: Cytoplasm, cytoskeleton; Cell projection, ruffle membrane; Endoplasmic reticulum; Golgi apparatus (UniProt). Locus 3p25.1 (HGNC).
Query for this target: (TITLE:"FGD5" OR ABSTRACT:"FGD5" OR TITLE:"FYVE, RhoGEF and PH domain containing 5" OR ABSTRACT:"FYVE, RhoGEF and PH domain containing 5" OR TITLE:"FYVE, RhoGEF and PH domain-containing protein 5" OR ABSTRACT:"FYVE, RhoGEF and PH domain-containing protein 5" OR TITLE:"ZFYVE23" OR ABSTRACT:"ZFYVE23" OR TITLE:"FLJ39957" OR ABSTRACT:"FLJ39957" OR TITLE:"FLJ00274" OR ABSTRACT:"FLJ00274") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGD5, not a curated reading list.