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FGD5 (FYVE, RhoGEF and PH domain-containing protein 5) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Acute myeloid leukaemia. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape. Location: Cytoplasm, cytoskeleton; Cell projection, ruffle membrane; Endoplasmic reticulum; Golgi apparatus (UniProt). Locus 3p25.1 (HGNC).
No product in the corpus is aimed at this target yet.
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"FGD5" OR ABSTRACT:"FGD5" OR TITLE:"FYVE, RhoGEF and PH domain containing 5" OR ABSTRACT:"FYVE, RhoGEF and PH domain containing 5" OR TITLE:"FYVE, RhoGEF and PH domain-containing protein 5" OR ABSTRACT:"FYVE, RhoGEF and PH domain-containing protein 5" OR TITLE:"ZFYVE23" OR ABSTRACT:"ZFYVE23" OR TITLE:"FLJ39957" OR ABSTRACT:"FLJ39957" OR TITLE:"FLJ00274" OR ABSTRACT:"FLJ00274") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FGD5, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/fgd5.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/fgd5.json. Licence CC BY-NC 4.0.