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FEV (FEV transcription factor, ETS family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.67, genetic association 0.00, somatic mutation 0.92).
In plain words · FEV (FEV transcription factor, ETS family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
FEV (FEV transcription factor, ETS family member) is a protein that switches other genes on and off. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor.
No product in this corpus aims at FEV yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1997. Earliest sequence paper UniProt cites for the protein: Peter et al, Oncogene, 1997, "A new member of the ETS family fused to EWS in Ewing tumors". Source.
Sources: HGNC HGNC:18562 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q99581 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000163497 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Functions as a transcriptional regulator. According to PubMed:12761502, it functions as a transcriptional repressor. Functions in the differentiation and the maintenance of the central serotonergic neurons. May play a role in cell growth. Location: Nucleus (UniProt). Locus 2q35 (HGNC).
Query for this target: (TITLE:"FEV" OR ABSTRACT:"FEV" OR TITLE:"FEV transcription factor, ETS family member" OR ABSTRACT:"FEV transcription factor, ETS family member" OR TITLE:"Pet-1" OR ABSTRACT:"Pet-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FEV, not a curated reading list.