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FERMT2 (Fermitin family homolog 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.43, genetic association 0.61).
In plain words · FERMT2 (Fermitin family homolog 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
FERMT2 (Fermitin family homolog 2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides.
No product in this corpus aims at FERMT2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1994. Earliest sequence paper UniProt cites for the protein: Wick et al, J. Cell Sci, 1994, "Identification of serum-inducible genes: different patterns of gene regulation during G0->S and G1->S progression". Source.
Sources: HGNC HGNC:15767 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96AC1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000073712 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Location: Cytoplasm; Cytoplasm, cell cortex; Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, stress fiber (UniProt). Locus 14q22.1 (HGNC).
Query for this target: (TITLE:"FERMT2" OR ABSTRACT:"FERMT2" OR TITLE:"FERM domain containing kindlin 2" OR ABSTRACT:"FERM domain containing kindlin 2" OR TITLE:"Fermitin family homolog 2" OR ABSTRACT:"Fermitin family homolog 2" OR TITLE:"mig-2" OR ABSTRACT:"mig-2" OR TITLE:"KIND2" OR ABSTRACT:"KIND2" OR TITLE:"UNC112B" OR ABSTRACT:"UNC112B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FERMT2, not a curated reading list.