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FAT2 (Protocadherin Fat 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Vulvar cancer.
Involved in the regulation of cell migration. May be involved in mediating the organisation of the parallel fibres of granule cells during cerebellar development.
IntOGen calls it a driver in 1 cohort (0 activating, 1 loss-of-function), covering Vulva/Vagina.
In plain words · FAT2 (Protocadherin Fat 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Vulvar cancer.
FAT2 (Protocadherin Fat 2) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Vulvar cancer.
Involved in the regulation of cell migration. May be involved in mediating the organisation of the parallel fibres of granule cells during cerebellar development.
No product in this corpus aims at FAT2 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 1998. Earliest sequence paper UniProt cites for the protein: Nakayama et al, Genomics, 1998, "Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening". Source.
Sources: HGNC HGNC:3596 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9NYQ8 (protein name, function text, keywords and locations (REST API)); IntOGen FAT2 (driver in 1 cohort (Act 0, LoF 1); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Involved in the regulation of cell migration. May be involved in mediating the organisation of the parallel fibres of granule cells during cerebellar development. Location: Cell membrane; Cell junction; Golgi apparatus, trans-Golgi network (UniProt). Locus 5q33.1 (HGNC).
Query for this target: (TITLE:"FAT2" OR ABSTRACT:"FAT2" OR TITLE:"FAT atypical cadherin 2" OR ABSTRACT:"FAT atypical cadherin 2" OR TITLE:"Protocadherin Fat 2" OR ABSTRACT:"Protocadherin Fat 2" OR TITLE:"MEGF1" OR ABSTRACT:"MEGF1" OR TITLE:"CDHF8" OR ABSTRACT:"CDHF8" OR TITLE:"HFAT2" OR ABSTRACT:"HFAT2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAT2, not a curated reading list.
Shares Vulvar cancer, IntOGen.
Shares Vulvar cancer, IntOGen.
Shares Vulvar cancer, IntOGen.
Shares Vulvar cancer, IntOGen.