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FANCB (Fanconi anaemia group B protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
DNA repair protein required for FANCD2 ubiquitination.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.72, genetic association 0.18, genetic literature 0.83).
In plain words · FANCB (Fanconi anaemia group B protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
FANCB (Fanconi anaemia group B protein) is a gene. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
DNA repair protein required for FANCD2 ubiquitination. Location: Nucleus (UniProt).
No product in this corpus aims at FANCB yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:3583 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8NB91 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000181544 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
DNA repair protein required for FANCD2 ubiquitination. Location: Nucleus (UniProt). Locus Xp22.2 (HGNC).
Query for this target: (TITLE:"FANCB" OR ABSTRACT:"FANCB" OR TITLE:"FA complementation group B" OR ABSTRACT:"FA complementation group B" OR TITLE:"Fanconi anemia group B protein" OR ABSTRACT:"Fanconi anemia group B protein" OR TITLE:"FLJ34064" OR ABSTRACT:"FLJ34064" OR TITLE:"FAAP95" OR ABSTRACT:"FAAP95") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FANCB, not a curated reading list.