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FAAP20 (Fanconi anaemia core complex-associated protein 20) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Component of the Fanconi anaemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognises and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Interventional Radiology Procedure and PARP Inhibitor AZD2461.
In plain words · FAAP20 (Fanconi anaemia core complex-associated protein 20) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
FAAP20 (Fanconi anaemia core complex-associated protein 20) is a gene. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response.
Component of the Fanconi anaemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair.
No product in this corpus aims at FAAP20 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA FAAP20: RNA low tissue specificity; no normal tissue stained high; highest cancer staining colorectal cancer (5 of 11 high). Distribution: no corpus cancer carries a prevalence row, threshold or catalogue link for it; Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas FAAP20 tissue; Open Targets ENSG00000162585 associations
First described 2004. Earliest sequence paper UniProt cites for the protein: Ota et al, Nat. Genet, 2004, "Complete sequencing and characterization of 21,243 full-length human cDNAs". Source.
Sources: HGNC HGNC:26428 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6NZ36 (protein name, function text, keywords and locations (REST API)); CIViC gene FAAP20 (2 evidence items, 0 assertions, 1 variants; diseases: Cancer (GraphQL API, CC0))
Component of the Fanconi anaemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognises and binds 'Lys-63'-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1. Location: Nucleus; Chromosome (UniProt). Locus 1p36.33 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
No normal tissue stained high.
Medium only: carcinoid, cervical cancer, head and neck cancer, lung cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"FAAP20" OR ABSTRACT:"FAAP20" OR TITLE:"FA core complex associated protein 20" OR ABSTRACT:"FA core complex associated protein 20" OR TITLE:"Fanconi anemia core complex-associated protein 20" OR ABSTRACT:"Fanconi anemia core complex-associated protein 20" OR TITLE:"FLJ31031" OR ABSTRACT:"FLJ31031" OR TITLE:"C1orf86" OR ABSTRACT:"C1orf86") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAAP20, not a curated reading list.