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EXO1 (Exonuclease 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment.
Open Targets scores its association with cancer at 0.68 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.87, genetic association 0.74, genetic literature 0.01).
In plain words · EXO1 (Exonuclease 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
EXO1 (Exonuclease 1) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role. Tied to Breast cancer.
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity.
No product in this corpus aims at EXO1 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1998. Earliest sequence paper UniProt cites for the protein: Schmutte et al, Cancer Res, 1998, "Human exonuclease I interacts with the mismatch repair protein hMSH2". Source.
Sources: HGNC HGNC:3511 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UQ84 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000174371 (association with cancer (MONDO_0004992) 0.68; per-cancer scores at or above 0.5: breast cancer 0.54 (GraphQL API, CC0))
5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair (MMR) to excise mismatch-containing DNA tracts directed by strand breaks located either 5' or 3' to the mismatch. Also exhibits endonuclease activity against 5'-overhanging flap structures similar to those generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Required for somatic hypermutation (SHM) and class switch recombination (CSR) of immunoglobulin genes. Essential for male and female meiosis. Location: Nucleus (UniProt). Locus 1q43 (HGNC).
Query for this target: (TITLE:"EXO1" OR ABSTRACT:"EXO1" OR TITLE:"exonuclease 1" OR ABSTRACT:"exonuclease 1" OR TITLE:"Exonuclease 1" OR ABSTRACT:"Exonuclease 1" OR TITLE:"HEX1" OR ABSTRACT:"HEX1" OR TITLE:"hExoI" OR ABSTRACT:"hExoI") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EXO1, not a curated reading list.
Shares Mismatch repair & microsatellite instability, Open Targets Platform.
Shares Mismatch repair & microsatellite instability, Breast cancer (all types), Open Targets Platform.
Shares Mismatch repair & microsatellite instability, Breast cancer (all types), Open Targets Platform.
Shares Mismatch repair & microsatellite instability, Breast cancer (all types), Open Targets Platform.