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ESRP1 (Epithelial splicing regulatory protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT).
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.98, affected pathway 0.89, animal model 0.64, genetic association 0.00).
In plain words · ESRP1 (Epithelial splicing regulatory protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
ESRP1 (Epithelial splicing regulatory protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2.
No product in this corpus aims at ESRP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Genome Res, 2004, "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Source.
Sources: HGNC HGNC:25966 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6NXG1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000104413 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2. Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium. Location: Nucleus (UniProt). Locus 8q22.1 (HGNC).
Query for this target: (TITLE:"ESRP1" OR ABSTRACT:"ESRP1" OR TITLE:"epithelial splicing regulatory protein 1" OR ABSTRACT:"epithelial splicing regulatory protein 1" OR TITLE:"Epithelial splicing regulatory protein 1" OR ABSTRACT:"Epithelial splicing regulatory protein 1" OR TITLE:"FLJ20171" OR ABSTRACT:"FLJ20171" OR TITLE:"RBM35A" OR ABSTRACT:"RBM35A") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ESRP1, not a curated reading list.