Loading
ERRFI1 (ERBB receptor feedback inhibitor 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Biliary tract cancer and Non-small-cell lung cancer.
Negative regulator of EGFR signalling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerisation.
CIViC holds 2 clinical evidence items and 0 assertions across 4 variants, naming Erlotinib and Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor.
In plain words · ERRFI1 (ERBB receptor feedback inhibitor 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Biliary tract cancer and Non-small-cell lung cancer.
ERRFI1 (ERBB receptor feedback inhibitor 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Biliary tract cancer and Non-small-cell lung cancer.
Negative regulator of EGFR signalling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4.
No product in this corpus aims at ERRFI1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA ERRFI1: RNA tissue enhanced (liver 695 nTPM, pancreas 640 nTPM); blood lineage lineage enriched (monocytes 2 nTPM); no normal tissue stained high. Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Biliary tract cancer (all types), Lung cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas ERRFI1 tissue; Open Targets ENSG00000116285 associations
First described 1995. Earliest sequence paper UniProt cites for the protein: Wick et al, Exp. Cell Res, 1995, "Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation". Source.
Sources: HGNC HGNC:18185 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UJM3 (protein name, function text, keywords and locations (REST API)); CIViC gene ERRFI1 (2 evidence items, 0 assertions, 4 variants; diseases: Cholangiocarcinoma, Lung Non-small Cell Carcinoma (GraphQL API, CC0))
Negative regulator of EGFR signalling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerisation. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Location: Cytoplasm; Cell membrane; Nucleus (UniProt). Locus 1p36.23 (HGNC).
RNA: tissue enhanced (liver 695 nTPM, pancreas 640 nTPM), detected in all normal tissues. Blood: lineage enriched (monocytes 2 nTPM).
No normal tissue stained high.
No cancer sample stained medium or high.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"ERRFI1" OR ABSTRACT:"ERRFI1" OR TITLE:"ERBB receptor feedback inhibitor 1" OR ABSTRACT:"ERBB receptor feedback inhibitor 1" OR TITLE:"MIG-6" OR ABSTRACT:"MIG-6" OR TITLE:"GENE-33" OR ABSTRACT:"GENE-33") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERRFI1, not a curated reading list.