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ERLIN2 (Erlin-2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signalling pathway.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.95, genetic association 0.23).
In plain words · ERLIN2 (Erlin-2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
ERLIN2 (Erlin-2) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1.
No product in this corpus aims at ERLIN2 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Ikegawa et al, Cytogenet. Cell Genet, 1999, "Cloning and characterization of a novel gene (C8orf2), a human representative of a novel gene family with homology to C. elegans C42.C1.9". Source.
Sources: HGNC HGNC:1356 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O94905 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000147475 (association with cancer (MONDO_0004992) 0.64; (GraphQL API, CC0))
Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs) such as ITPR1. Promotes sterol-accelerated ERAD of HMGCR probably implicating an AMFR/gp78-containing ubiquitin ligase complex. Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signalling pathway. May promote ER retention of the SCAP-SREBF complex. Location: Endoplasmic reticulum membrane (UniProt). Locus 8p11.23 (HGNC).
Query for this target: (TITLE:"ERLIN2" OR ABSTRACT:"ERLIN2" OR TITLE:"ER lipid raft associated 2" OR ABSTRACT:"ER lipid raft associated 2" OR TITLE:"Erlin-2" OR ABSTRACT:"Erlin-2" OR TITLE:"NET32" OR ABSTRACT:"NET32" OR TITLE:"C8orf2" OR ABSTRACT:"C8orf2" OR TITLE:"SPFH2" OR ABSTRACT:"SPFH2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERLIN2, not a curated reading list.