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ERC1 (ELKS/Rab6-interacting/CAST family member 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organisation of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.38, animal model 0.42, genetic association 0.08, somatic mutation 0.92).
In plain words · ERC1 (ELKS/Rab6-interacting/CAST family member 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
ERC1 (ELKS/Rab6-interacting/CAST family member 1) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role.
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex.
No product in this corpus aims at ERC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Nakata et al, Genes Chromosomes Cancer, 1999, "Fusion of a novel gene, ELKS, to RET due to translocation t(10;12)(q11;p13) in a papillary thyroid carcinoma". Source.
Sources: HGNC HGNC:17072 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q8IUD2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000082805 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex. May be involved in the organisation of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport. Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm; Membrane; Golgi apparatus membrane (UniProt). Locus 12p13.33 (HGNC).
Query for this target: (TITLE:"ERC1" OR ABSTRACT:"ERC1" OR TITLE:"ELKS/RAB6-interacting/CAST family member 1" OR ABSTRACT:"ELKS/RAB6-interacting/CAST family member 1" OR TITLE:"ELKS/Rab6-interacting/CAST family member 1" OR ABSTRACT:"ELKS/Rab6-interacting/CAST family member 1" OR TITLE:"KIAA1081" OR ABSTRACT:"KIAA1081" OR TITLE:"CAST2" OR ABSTRACT:"CAST2" OR TITLE:"MGC12974" OR ABSTRACT:"MGC12974") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ERC1, not a curated reading list.