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EMSY (BRCA2-interacting transcriptional repressor EMSY) is a protein that switches other genes on and off. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors.
CIViC holds 2 clinical evidence items and 0 assertions across 2 variants, naming Bevacizumab, Paclitaxel, Carboplatin and Talazoparib.
In plain words · EMSY (BRCA2-interacting transcriptional repressor EMSY) is a protein that switches other genes on and off. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
EMSY (BRCA2-interacting transcriptional repressor EMSY) is a protein that switches other genes on and off. The public catalogues list it as a drug target, a biomarker and a DNA repair gene, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Ovarian cancer.
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin.
No product in this corpus aims at EMSY yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
Broadly expressed or essential: HPA finds the RNA at low tissue specificity; a medicine acting on the wild-type protein would expose normal tissue too. HPA EMSY: RNA low tissue specificity; high antibody staining in 17 normal tissues; highest cancer staining colorectal cancer (7 of 11 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Ovarian cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (Rule 7 of scripts/fetch-target-specificity.ts.)
Sources: Human Protein Atlas EMSY tissue; Open Targets ENSG00000158636 associations
First described 2000. Earliest sequence paper UniProt cites for the protein: Li et al, 2000, "A novel gene expressed in human liver non-tumor tissues". Source.
Sources: HGNC HGNC:18071 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q7Z589 (protein name, function text, keywords and locations (REST API)); CIViC gene EMSY (2 evidence items, 0 assertions, 2 variants; diseases: Ovarian Serous Carcinoma, Acral Lentiginous Melanoma (GraphQL API, CC0))
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2. Mediates ligand-dependent transcriptional activation by nuclear hormone receptors. Location: Nucleus (UniProt). Locus 11q13.5 (HGNC).
RNA: low tissue specificity, detected in all normal tissues.
Medium: Adrenal gland, Appendix, Bone marrow, Breast, Cervix, Colon, Endometrium, Esophagus.
Medium only: head and neck cancer, lymphoma, pancreatic cancer, prostate cancer.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"EMSY" OR ABSTRACT:"EMSY" OR TITLE:"EMSY transcriptional repressor, BRCA2 interacting" OR ABSTRACT:"EMSY transcriptional repressor, BRCA2 interacting" OR TITLE:"BRCA2-interacting transcriptional repressor EMSY" OR ABSTRACT:"BRCA2-interacting transcriptional repressor EMSY" OR TITLE:"C11orf30" OR ABSTRACT:"C11orf30") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EMSY, not a curated reading list.