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ELP4 (Elongator complex protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma.
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyses the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.37, animal model 0.57, genetic association 0.80).
In plain words · ELP4 (Elongator complex protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma.
ELP4 (Elongator complex protein 4) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Renal cell carcinoma.
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).
No product in this corpus aims at ELP4 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2001. Earliest sequence paper UniProt cites for the protein: Wiemann et al, Genome Res, 2001, "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Source.
Sources: HGNC HGNC:1171 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96EB1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000109911 (association with cancer (MONDO_0004992) 0.51; per-cancer scores at or above 0.5: renal cell carcinoma 0.50 (GraphQL API, CC0))
Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyses the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. Location: Cytoplasm; Nucleus (UniProt). Locus 11p13 (HGNC).
Query for this target: (TITLE:"ELP4" OR ABSTRACT:"ELP4" OR TITLE:"elongator acetyltransferase complex subunit 4" OR ABSTRACT:"elongator acetyltransferase complex subunit 4" OR TITLE:"Elongator complex protein 4" OR ABSTRACT:"Elongator complex protein 4" OR TITLE:"PAXNEB" OR ABSTRACT:"PAXNEB" OR TITLE:"C11orf19" OR ABSTRACT:"C11orf19") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ELP4, not a curated reading list.