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ELK4 (ETS domain-containing protein Elk-4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma and Skin cancer.
Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilisation of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF).
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.90, animal model 0.28, genetic association 0.00, somatic mutation 0.81). IntOGen calls it a driver in 1 cohort (1 activating, 0 loss-of-function), covering Head and Neck Squamous Cell Carcinoma.
In plain words · ELK4 (ETS domain-containing protein Elk-4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma and Skin cancer.
ELK4 (ETS domain-containing protein Elk-4) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Head and neck squamous cell carcinoma and Skin cancer.
Involved in both transcriptional activation and repression.
No product in this corpus aims at ELK4 yet. Drugs fit a pocket that exists only in one shape of the mutant protein and hold it there, off.
First described 1992. Earliest sequence paper UniProt cites for the protein: Dalton et al, Cell, 1992, "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element". Source.
Sources: HGNC HGNC:3326 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P28324 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000158711 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: skin cancer 0.51 (GraphQL API, CC0)); IntOGen ELK4 (driver in 1 cohort (Act 1, LoF 0); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Involved in both transcriptional activation and repression. Interaction with SIRT7 leads to recruitment and stabilisation of SIRT7 at promoters, followed by deacetylation of histone H3 at 'Lys-18' (H3K18Ac) and subsequent transcription repression. Forms a ternary complex with the serum response factor (SRF). Requires DNA-bound SRF for ternary complex formation and makes extensive DNA contacts to the 5'side of SRF, but does not bind DNA autonomously. Location: Nucleus (UniProt). Locus 1q32.1 (HGNC).
Query for this target: (TITLE:"ELK4" OR ABSTRACT:"ELK4" OR TITLE:"ETS transcription factor ELK4" OR ABSTRACT:"ETS transcription factor ELK4" OR TITLE:"ETS domain-containing protein Elk-4" OR ABSTRACT:"ETS domain-containing protein Elk-4" OR TITLE:"SAP1" OR ABSTRACT:"SAP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ELK4, not a curated reading list.