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ELAC2 (Zinc phosphodiesterase ELAC protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly.
Open Targets scores its association with cancer at 0.74 (direct and indirect evidence; datatypes literature 0.74, animal model 0.70, genetic association 0.84, genetic literature 0.61).
In plain words · ELAC2 (Zinc phosphodiesterase ELAC protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
ELAC2 (Zinc phosphodiesterase ELAC protein 2) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Prostate cancer.
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA.
No product in this corpus aims at ELAC2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 2001. Earliest sequence paper UniProt cites for the protein: Tavtigian S.V. et al, Nat. Genet, 2001, "A candidate prostate cancer susceptibility gene at chromosome 17p". Source.
Sources: HGNC HGNC:14198 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BQ52 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000006744 (association with cancer (MONDO_0004992) 0.74; per-cancer scores at or above 0.5: prostate cancer 0.74 (GraphQL API, CC0))
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. Location: Mitochondrion; Mitochondrion matrix, mitochondrion nucleoid; Nucleus (UniProt). Locus 17p12 (HGNC).
Query for this target: (TITLE:"ELAC2" OR ABSTRACT:"ELAC2" OR TITLE:"elaC ribonuclease Z 2" OR ABSTRACT:"elaC ribonuclease Z 2" OR TITLE:"Zinc phosphodiesterase ELAC protein 2" OR ABSTRACT:"Zinc phosphodiesterase ELAC protein 2" OR TITLE:"FLJ10530" OR ABSTRACT:"FLJ10530" OR TITLE:"HPC2" OR ABSTRACT:"HPC2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ELAC2, not a curated reading list.