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EIF4EBP1 (Eukaryotic translation initiation factor 4E-binding protein 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Gastric & gastro-oesophageal junction cancer.
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways.
CIViC holds 2 clinical evidence items and 0 assertions across 1 variant, naming Everolimus, MTOR Kinase Inhibitor PP242, WYE354 and Dactolisib.
In plain words · EIF4EBP1 (Eukaryotic translation initiation factor 4E-binding protein 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Gastric & gastro-oesophageal junction cancer.
EIF4EBP1 (Eukaryotic translation initiation factor 4E-binding protein 1) is a gene. The public catalogues list it as a drug target and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer and Gastric & gastro-oesophageal junction cancer.
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation.
No product in this corpus aims at EIF4EBP1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the roles drug-target, biomarker; HPA finds the RNA tissue enhanced, which says where the protein sits but not whether the tumour differs from normal tissue. HPA EIF4EBP1: RNA tissue enhanced (pancreas 310 nTPM); high antibody staining in 11 normal tissues; highest cancer staining testis cancer (12 of 12 high). Distribution: 2 cancer families in the corpus carry a prevalence row, label threshold or catalogue link for it (Colorectal cancer, Gastric & gastro-oesophageal junction cancer); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas EIF4EBP1 tissue; Open Targets ENSG00000187840 associations
First described 1994. Earliest sequence paper UniProt cites for the protein: Pause et al, Nature, 1994, "Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function". Source.
Sources: HGNC HGNC:3288 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13541 (protein name, function text, keywords and locations (REST API)); CIViC gene EIF4EBP1 (2 evidence items, 0 assertions, 1 variants; diseases: Colorectal Cancer, Gastric Adenocarcinoma (GraphQL API, CC0))
Repressor of translation initiation that regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation. Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. Location: Cytoplasm; Nucleus (UniProt). Locus 8p11.23 (HGNC).
RNA: tissue enhanced (pancreas 310 nTPM), detected in all normal tissues.
Medium: Appendix, Breast, Caudate, Cervix, Endometrium, Fallopian tube, Kidney, Lung.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"EIF4EBP1" OR ABSTRACT:"EIF4EBP1" OR TITLE:"eukaryotic translation initiation factor 4E binding protein 1" OR ABSTRACT:"eukaryotic translation initiation factor 4E binding protein 1" OR TITLE:"Eukaryotic translation initiation factor 4E-binding protein 1" OR ABSTRACT:"Eukaryotic translation initiation factor 4E-binding protein 1" OR TITLE:"PHAS-I" OR ABSTRACT:"PHAS-I" OR TITLE:"4E-BP1" OR ABSTRACT:"4E-BP1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EIF4EBP1, not a curated reading list.