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EBF2 (Transcription factor COE2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognises variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.36, animal model 0.53, genetic association 0.64).
In plain words · EBF2 (Transcription factor COE2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
EBF2 (Transcription factor COE2) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway.
No product in this corpus aims at EBF2 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 2004. Earliest sequence paper UniProt cites for the protein: Li et al, 2004. Source.
Sources: HGNC HGNC:19090 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9HAK2 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000221818 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Transcription factor that, in osteoblasts, activates the decoy receptor for RANKL, TNFRSF11B, which in turn regulates osteoclast differentiation. Acts in synergy with the Wnt-responsive LEF1/CTNNB1 pathway. Recognises variations of the palindromic sequence 5'-ATTCCCNNGGGAATT-3'. Location: Nucleus (UniProt). Locus 8p21.2 (HGNC).
Query for this target: (TITLE:"EBF2" OR ABSTRACT:"EBF2" OR TITLE:"EBF transcription factor 2" OR ABSTRACT:"EBF transcription factor 2" OR TITLE:"Transcription factor COE2" OR ABSTRACT:"Transcription factor COE2" OR TITLE:"FLJ11500" OR ABSTRACT:"FLJ11500" OR TITLE:"COE2" OR ABSTRACT:"COE2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EBF2, not a curated reading list.