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DUSP16 (Dual specificity protein phosphatase 16) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
IntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Colorectal Adenocarcinoma.
In plain words · DUSP16 (Dual specificity protein phosphatase 16) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
DUSP16 (Dual specificity protein phosphatase 16) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.
No product in this corpus aims at DUSP16 yet. Because the protein is lost rather than overactive, drugs either restore its function or exploit the weakness its loss leaves (synthetic lethality).
First described 2000. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". Source.
Sources: HGNC HGNC:17909 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BY84 (protein name, function text, keywords and locations (REST API)); IntOGen DUSP16 (driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0)
Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. Location: Cytoplasm; Nucleus; Cytoplasmic vesicle (UniProt). Locus 12p13.2 (HGNC).
Query for this target: (TITLE:"DUSP16" OR ABSTRACT:"DUSP16" OR TITLE:"dual specificity phosphatase 16" OR ABSTRACT:"dual specificity phosphatase 16" OR TITLE:"Dual specificity protein phosphatase 16" OR ABSTRACT:"Dual specificity protein phosphatase 16" OR TITLE:"MKP-7" OR ABSTRACT:"MKP-7" OR TITLE:"KIAA1700" OR ABSTRACT:"KIAA1700" OR TITLE:"MKP7" OR ABSTRACT:"MKP7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DUSP16, not a curated reading list.