{"entity":{"id":"dusp16","kind":"target","name":"DUSP16","aka":["dual specificity phosphatase 16","Dual specificity protein phosphatase 16","MKP-7","KIAA1700","MKP7"],"tldr":"DUSP16 (Dual specificity protein phosphatase 16) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Colorectal cancer.","summary":"Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2.\n\nIntOGen calls it a driver in 2 cohorts (0 activating, 2 loss-of-function), covering Colorectal Adenocarcinoma.","asOf":"2026-09-23","links":[{"label":"HGNC HGNC:17909","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17909"},{"label":"UniProt Q9BY84","url":"https://www.uniprot.org/uniprotkb/Q9BY84/entry"},{"label":"NCBI Gene 80824","url":"https://www.ncbi.nlm.nih.gov/gene/80824"},{"label":"Ensembl ENSG00000111266","url":"https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000111266"}],"tags":["cancer-genes-wave"],"related":["intogen"],"cancers":["colorectal"],"sections":[],"technologies":[],"targets":[],"drugs":[],"companies":[],"institutions":[],"pathways":[],"terms":[],"trials":[],"people":[],"bottlenecks":[],"keyPapers":[],"journals":[],"dependsOn":[],"notes":["Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: IntOGen calls it a loss-of-function (LoF) driver in 2 cohorts. Evidence tier \"cohort-driver\" is the strongest of those signals.","Prevalence not recorded: none of the sources gives a positivity rate."],"provenance":{"editedBy":"scripts/fetch-cancer-genes.ts (CIViC, Open Targets, IntOGen, HGNC, UniProt)","editedOn":"2026-09-23"},"symbol":"DUSP16","role":["tumour-suppressor"],"evidenceTier":"cohort-driver","sources":[{"label":"HGNC HGNC:17909","url":"https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17909","note":"approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)"},{"label":"UniProt Q9BY84","url":"https://www.uniprot.org/uniprotkb/Q9BY84/entry","note":"protein name, function text, keywords and locations (REST API)"},{"label":"IntOGen DUSP16","url":"https://www.intogen.org/search?gene=DUSP16","note":"driver in 2 cohorts (Act 0, LoF 2); Compendium_Cancer_Genes.tsv release 20240920, CC0 1.0"}],"specificitySources":[],"hgnc":"HGNC:17909","ensembl":"ENSG00000111266","uniprot":"Q9BY84","entrez":"80824","firstDescribed":2000,"firstDescribedBasis":"sequence","firstDescribedNote":"Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 2000, \"Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro\".","firstDescribedSource":"https://pubmed.ncbi.nlm.nih.gov/11214970/","biology":"Dual specificity protein phosphatase involved in the inactivation of MAP kinases. Dephosphorylates MAPK10 bound to ARRB2. Location: Cytoplasm; Nucleus; Cytoplasmic vesicle (UniProt). Locus 12p13.2 (HGNC).","whereFound":["Colorectal cancer: IntOGen driver in 2 cohorts (COADREAD)"],"targetClass":"tumor-suppressor","prevalence":[]},"route":"/targets/dusp16/","neighbours":{"collection":[{"id":"intogen","kind":"collection","name":"IntOGen","route":"/collections/intogen/"}],"cancer":[{"id":"colorectal","kind":"cancer","name":"Colorectal cancer","route":"/cancers/colorectal/"}]}}