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DNMT3B (DNA (cytosine-5)-methyltransferase 3B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region.
Open Targets scores its association with cancer at 0.58 (direct and indirect evidence; datatypes literature 0.99, affected pathway 0.76, genetic association 0.54).
In plain words · DNMT3B (DNA (cytosine-5)-methyltransferase 3B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
DNMT3B (DNA (cytosine-5)-methyltransferase 3B) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role.
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones.
No product in this corpus aims at DNMT3B yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1999. Earliest sequence paper UniProt cites for the protein: Xie et al, Gene, 1999, "Cloning, expression and chromosome locations of the human DNMT3 gene family". Source.
Sources: HGNC HGNC:2979 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9UBC3 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000088305 (association with cancer (MONDO_0004992) 0.58; (GraphQL API, CC0))
Required for genome-wide de novo methylation and is essential for the establishment of DNA methylation patterns during development. DNA methylation is coordinated with methylation of histones. May preferentially methylates nucleosomal DNA within the nucleosome core region. May function as transcriptional co-repressor by associating with CBX4 and independently of DNA methylation. Seems to be involved in gene silencing. In association with DNMT1 and via the recruitment of CTCFL/BORIS, involved in activation of BAG1 gene expression by modulating dimethylation of promoter histone H3 at H3K4 and H3K9. Location: Nucleus (UniProt). Locus 20q11.21 (HGNC).
Query for this target: (TITLE:"DNMT3B" OR ABSTRACT:"DNMT3B" OR TITLE:"DNA methyltransferase 3 beta" OR ABSTRACT:"DNA methyltransferase 3 beta" OR TITLE:"DNA cytosine-5 -methyltransferase 3B" OR ABSTRACT:"DNA cytosine-5 -methyltransferase 3B") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNMT3B, not a curated reading list.