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DNAJC1 (DnaJ homolog subfamily C member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
May modulate protein synthesis.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.71, genetic association 0.65).
In plain words · DNAJC1 (DnaJ homolog subfamily C member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
DNAJC1 (DnaJ homolog subfamily C member 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
May modulate protein synthesis. Location: Endoplasmic reticulum membrane; Nucleus membrane; Microsome membrane (UniProt).
No product in this corpus aims at DNAJC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 2004. Earliest sequence paper UniProt cites for the protein: Kroczynska et al, J. Biol. Chem, 2004, "The SANT2 domain of the murine tumor cell DnaJ-like protein 1 human homologue interacts with alpha1-antichymotrypsin and kinetically interferes with its serpin inhibitory activity". Source.
Sources: HGNC HGNC:20090 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96KC8 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000136770 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
May modulate protein synthesis. Location: Endoplasmic reticulum membrane; Nucleus membrane; Microsome membrane (UniProt). Locus 10p12.31 (HGNC).
Query for this target: (TITLE:"DNAJC1" OR ABSTRACT:"DNAJC1" OR TITLE:"DnaJ heat shock protein family Hsp40 member C1" OR ABSTRACT:"DnaJ heat shock protein family Hsp40 member C1" OR TITLE:"DnaJ homolog subfamily C member 1" OR ABSTRACT:"DnaJ homolog subfamily C member 1" OR TITLE:"DNAJL1" OR ABSTRACT:"DNAJL1" OR TITLE:"ERdj1" OR ABSTRACT:"ERdj1" OR TITLE:"MTJ1" OR ABSTRACT:"MTJ1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNAJC1, not a curated reading list.