Loading
DNAH11 (Dynein axonemal heavy chain 11) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Force generating protein required for cilia beating in respiratory epithelia. Produces force towards the minus ends of microtubules. Key component of dynein, a family of motor proteins essential for movement along microtubules.
Open Targets scores its association with cancer at 0.51 (direct and indirect evidence; datatypes literature 0.24, animal model 0.40, genetic association 0.66).
In plain words · DNAH11 (Dynein axonemal heavy chain 11) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
DNAH11 (Dynein axonemal heavy chain 11) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Force generating protein required for cilia beating in respiratory epithelia. Produces force towards the minus ends of microtubules.
No product in this corpus aims at DNAH11 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Maiti A.K. et al, 1999, "Chromosomal localization of human dynein heavy chain genes". Source.
Sources: HGNC HGNC:2942 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96DT5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000105877 (association with cancer (MONDO_0004992) 0.51; (GraphQL API, CC0))
Force generating protein required for cilia beating in respiratory epithelia. Produces force towards the minus ends of microtubules. Key component of dynein, a family of motor proteins essential for movement along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required for structural and functional integrity of cilia. Location: Cytoplasm, cytoskeleton, cilium axoneme (UniProt). Locus 7p15.3 (HGNC).
Query for this target: (TITLE:"DNAH11" OR ABSTRACT:"DNAH11" OR TITLE:"dynein axonemal heavy chain 11" OR ABSTRACT:"dynein axonemal heavy chain 11" OR TITLE:"Dynein axonemal heavy chain 11" OR ABSTRACT:"Dynein axonemal heavy chain 11" OR TITLE:"Dnahc11" OR ABSTRACT:"Dnahc11" OR TITLE:"DPL11" OR ABSTRACT:"DPL11" OR TITLE:"CILD7" OR ABSTRACT:"CILD7") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNAH11, not a curated reading list.