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DNA2 (DNA replication ATP-dependent helicase/nuclease DNA2) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA.
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.93, affected pathway 0.87, genetic association 0.03).
In plain words · DNA2 (DNA replication ATP-dependent helicase/nuclease DNA2) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
DNA2 (DNA replication ATP-dependent helicase/nuclease DNA2) is an enzyme. The public catalogues list it as a DNA repair gene, and the evidence so far is association rather than a proven role.
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion.
No product in this corpus aims at DNA2 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1995. Earliest sequence paper UniProt cites for the protein: Nagase et al, DNA Res, 1995, "Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1". Source.
Sources: HGNC HGNC:2939 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P51530 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000138346 (association with cancer (MONDO_0004992) 0.56; (GraphQL API, CC0))
Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair: recruited by BLM and mediates the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by the presence of RPA. Also involved in DNA replication checkpoint independently of Okazaki fragments processing. Possesses different enzymatic activities, such as single-stranded DNA (ssDNA)-dependent ATPase, 5'-3' helicase and endonuclease activities. While the ATPase and endonuclease activities are well-defined and play a key role in Okazaki fragments processing and DSB repair, the 5'-3' DNA helicase activity is subject to debate. Location: Nucleus; Mitochondrion (UniProt). Locus 10q21.3 (HGNC).
Query for this target: (TITLE:"DNA2" OR ABSTRACT:"DNA2" OR TITLE:"DNA replication helicase/nuclease 2" OR ABSTRACT:"DNA replication helicase/nuclease 2" OR TITLE:"DNA replication ATP-dependent helicase/nuclease DNA2" OR ABSTRACT:"DNA replication ATP-dependent helicase/nuclease DNA2" OR TITLE:"KIAA0083" OR ABSTRACT:"KIAA0083" OR TITLE:"DNA2L" OR ABSTRACT:"DNA2L") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DNA2, not a curated reading list.