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DLST (Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours.
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyses the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion.
In plain words · DLST (Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours.
DLST (Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Neuroendocrine tumours.
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyses the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2).
No product in this corpus aims at DLST yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1993. Earliest sequence paper UniProt cites for the protein: Nakano et al, Biochim. Biophys. Acta, 1993, "Human dihydrolipoamide succinyltransferase: cDNA cloning and localization on chromosome 14q24.2-q24.3". Source.
Sources: HGNC HGNC:2911 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P36957 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000119689 (per-cancer scores at or above 0.5: neuroendocrine neoplasm 0.66 (GraphQL API, CC0))
Dihydrolipoamide succinyltransferase (E2) component of the 2-oxoglutarate dehydrogenase complex. The 2-oxoglutarate dehydrogenase complex catalyses the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion. A fraction of the 2-oxoglutarate dehydrogenase complex also localises in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A. Location: Mitochondrion matrix; Nucleus (UniProt). Locus 14q24.3 (HGNC).
Query for this target: (TITLE:"DLST" OR ABSTRACT:"DLST" OR TITLE:"dihydrolipoamide S-succinyltransferase" OR ABSTRACT:"dihydrolipoamide S-succinyltransferase" OR TITLE:"Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial" OR ABSTRACT:"Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial" OR TITLE:"OGDC-E2" OR ABSTRACT:"OGDC-E2" OR TITLE:"KGD2" OR ABSTRACT:"KGD2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DLST, not a curated reading list.