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DLL1 (Delta-like protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner. Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signalling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signalling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes affected pathway 0.79, literature 0.94, genetic association 0.18, somatic mutation 0.23, animal model 0.54).
In plain words · DLL1 (Delta-like protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
DLL1 (Delta-like protein 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner.
No product in this corpus aims at DLL1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1999. Earliest sequence paper UniProt cites for the protein: Gray G.E. et al, Am. J. Pathol, 1999, "Human ligands of the Notch receptor". Source.
Sources: HGNC HGNC:2908 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O00548 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000198719 (association with cancer (MONDO_0004992) 0.63; (GraphQL API, CC0))
Transmembrane ligand protein of NOTCH1, NOTCH2 and NOTCH3 receptors that binds the extracellular domain (ECD) of Notch receptor in a cis and trans fashion manner. Following transinteraction, ligand cells produce mechanical force that depends of a clathrin-mediated endocytosis, requiring ligand ubiquitination, EPN1 interaction, and actin polymerisation; these events promote Notch receptor extracellular domain (NECD) transendocytosis and triggers Notch signalling through induction of cleavage, hyperphosphorylation, and nuclear accumulation of the intracellular domain of Notch receptors (NICD). Is required for embryonic development and maintenance of adult stem cells in many different tissues and immune systeme; the DLL1-induced Notch signalling is mediated through an intercellular communication that regulates cell lineage, cell specification, cell patterning and morphogenesis through effects on differentiation and proliferation. Plays a role in brain development at different level, namely by regulating neuronal differentiation of neural precursor cells via cell-cell interaction, most likely through the lateral inhibitory system in an endogenous level dependent-manner. During neocortex development, Dll1-Notch signalling transmission is mediated by dynamic interactions between intermediate neurogenic progenitors and radial glia; the cell-cell interactions are mediated via dynamic and transient elongation processes, likely to reactivate/maintain Notch activity in neighboring progenitors, and coordinate progenitor cell division and differentiation across radial and zonal boundaries. During cerebellar development, regulates Bergmann glial monolayer formation and its morphological maturation through a Notch signalling pathway. Location: Apical cell membrane; Cell junction, adherens junction; Membrane raft (UniProt). Locus 6q27 (HGNC).
Query for this target: (TITLE:"DLL1" OR ABSTRACT:"DLL1" OR TITLE:"delta like canonical Notch ligand 1" OR ABSTRACT:"delta like canonical Notch ligand 1" OR TITLE:"Delta-like protein 1" OR ABSTRACT:"Delta-like protein 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DLL1, not a curated reading list.