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DLC1 (Rho GTPase-activating protein 7) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signalling. This induces morphological changes and detachment through cytoskeletal reorganisation, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1.
Open Targets scores its association with cancer at 0.54 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.63, somatic mutation 0.55).
In plain words · DLC1 (Rho GTPase-activating protein 7) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
DLC1 (Rho GTPase-activating protein 7) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signalling.
No product in this corpus aims at DLC1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1997. Earliest sequence paper UniProt cites for the protein: Wei M.-H. et al, 1997, "Cloning and molecular characterization of the human ortholog of the rat dual regulator p122RhoGAP". Source.
Sources: HGNC HGNC:2897 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q96QB1 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000164741 (association with cancer (MONDO_0004992) 0.54; (GraphQL API, CC0))
Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signalling. This induces morphological changes and detachment through cytoskeletal reorganisation, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality. Required for growth factor-induced epithelial cell migration; in resting cells, interacts with TNS3 while PTEN interacts with the p85 regulatory subunit of the PI3K kinase complex but growth factor stimulation induces phosphorylation of TNS3 and PTEN, causing them to change their binding preference so that PTEN interacts with DLC1 and TNS3 interacts with p85. The PTEN-DLC1 complex translocates to the posterior of migrating cells to activate RHOA while the TNS3-p85 complex translocates to the leading edge of migrating cells to promote RAC1 activation. Location: Cytoplasm; Cell junction, focal adhesion; Membrane (UniProt). Locus 8p22 (HGNC).
Query for this target: (TITLE:"DLC1" OR ABSTRACT:"DLC1" OR TITLE:"DLC1 Rho GTPase activating protein" OR ABSTRACT:"DLC1 Rho GTPase activating protein" OR TITLE:"Rho GTPase-activating protein 7" OR ABSTRACT:"Rho GTPase-activating protein 7" OR TITLE:"ARHGAP7" OR ABSTRACT:"ARHGAP7" OR TITLE:"STARD12" OR ABSTRACT:"STARD12" OR TITLE:"DLC-1" OR ABSTRACT:"DLC-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DLC1, not a curated reading list.