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DEK (DEK proto-oncogene) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Gastric & gastro-oesophageal junction cancer.
Involved in chromatin organisation.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.99, genetic association 0.00, somatic mutation 0.97).
In plain words · DEK (DEK proto-oncogene) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Gastric & gastro-oesophageal junction cancer.
DEK (DEK proto-oncogene) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Breast cancer and Gastric & gastro-oesophageal junction cancer.
Involved in chromatin organisation. Location: Nucleus (UniProt).
No product in this corpus aims at DEK yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1992. Earliest sequence paper UniProt cites for the protein: Von Lindern et al, Mol. Cell. Biol, 1992, "The translocation (6;9), associated with a specific subtype of acute myeloid leukemia, results in the fusion of two genes, dek and can, and the expression of a chimeric, leukemia-specific dek-can mRNA". Source.
Sources: HGNC HGNC:2768 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P35659 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000124795 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: gastric cancer 0.51, breast cancer 0.53 (GraphQL API, CC0))
Involved in chromatin organisation. Location: Nucleus (UniProt). Locus 6p22.3 (HGNC).
Query for this target: (TITLE:"DEK" OR ABSTRACT:"DEK" OR TITLE:"DEK proto-oncogene" OR ABSTRACT:"DEK proto-oncogene" OR TITLE:"D6S231E" OR ABSTRACT:"D6S231E") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DEK, not a curated reading list.