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DDX5 (Probable ATP-dependent RNA helicase DDX5) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Skin cancer.
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.98, genetic association 0.00, somatic mutation 0.96).
In plain words · DDX5 (Probable ATP-dependent RNA helicase DDX5) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Skin cancer.
DDX5 (Probable ATP-dependent RNA helicase DDX5) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Colorectal cancer and Skin cancer.
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner.
No product in this corpus aims at DDX5 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
First described 1988. Earliest sequence paper UniProt cites for the protein: Ford M.J. et al, Nature, 1988, "Nuclear protein with sequence homology to translation initiation factor eIF-4A". Source.
Sources: HGNC HGNC:2746 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P17844 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000108654 (association with cancer (MONDO_0004992) 0.62; per-cancer scores at or above 0.5: colorectal cancer 0.53, skin cancer 0.51 (GraphQL API, CC0))
Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for androgen receptor AR but probably not ESR1. Synergises with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Location: Nucleus; Nucleus, nucleolus; Nucleus speckle; Cytoplasm (UniProt). Locus 17q23.3 (HGNC).
Query for this target: (TITLE:"DDX5" OR ABSTRACT:"DDX5" OR TITLE:"DEAD-box helicase 5" OR ABSTRACT:"DEAD-box helicase 5" OR TITLE:"Probable ATP-dependent RNA helicase DDX5" OR ABSTRACT:"Probable ATP-dependent RNA helicase DDX5" OR TITLE:"p68" OR ABSTRACT:"p68" OR TITLE:"HLR1" OR ABSTRACT:"HLR1" OR TITLE:"G17P1" OR ABSTRACT:"G17P1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DDX5, not a curated reading list.