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DDX10 (Probable ATP-dependent RNA helicase DDX10) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Skin cancer.
Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilising its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.87, animal model 0.31, genetic association 0.04, somatic mutation 0.98).
In plain words · DDX10 (Probable ATP-dependent RNA helicase DDX10) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Skin cancer.
DDX10 (Probable ATP-dependent RNA helicase DDX10) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Skin cancer.
Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilising its protein level.
No product in this corpus aims at DDX10 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1996. Earliest sequence paper UniProt cites for the protein: Savitsky et al, Genomics, 1996, "A human gene (DDX10) encoding a putative DEAD-box RNA helicase at 11q22-q23". Source.
Sources: HGNC HGNC:2735 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13206 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000178105 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: skin cancer 0.51, breast cancer 0.54 (GraphQL API, CC0))
Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilising its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression. Location: Cytoplasm; Nucleus; Nucleus, nucleolus (UniProt). Locus 11q22.3 (HGNC).
Query for this target: (TITLE:"DDX10" OR ABSTRACT:"DDX10" OR TITLE:"DEAD-box helicase 10" OR ABSTRACT:"DEAD-box helicase 10" OR TITLE:"Probable ATP-dependent RNA helicase DDX10" OR ABSTRACT:"Probable ATP-dependent RNA helicase DDX10" OR TITLE:"HRH-J8" OR ABSTRACT:"HRH-J8" OR TITLE:"Dbp4" OR ABSTRACT:"Dbp4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DDX10, not a curated reading list.