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DCTN1 (Dynactin subunit 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein.
Open Targets scores its association with cancer at 0.62 (direct and indirect evidence; datatypes literature 0.25, affected pathway 0.89, genetic association 0.00, somatic mutation 0.50).
In plain words · DCTN1 (Dynactin subunit 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
DCTN1 (Dynactin subunit 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules.
No product in this corpus aims at DCTN1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1996. Earliest sequence paper UniProt cites for the protein: Holzbaur E.L.F. et al, Genomics, 1996, "Localization of the DCTN1 gene encoding p150Glued to human chromosome 2p13 by fluorescence in situ hybridization". Source.
Sources: HGNC HGNC:2711 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q14203 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000204843 (association with cancer (MONDO_0004992) 0.62; (GraphQL API, CC0))
Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerisation and by inhibiting microtubule catastrophe in neurons. Location: Cytoplasm; Cytoplasm, cytoskeleton; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole (UniProt). Locus 2p13.1 (HGNC).
Query for this target: (TITLE:"DCTN1" OR ABSTRACT:"DCTN1" OR TITLE:"dynactin subunit 1" OR ABSTRACT:"dynactin subunit 1" OR TITLE:"Dynactin subunit 1" OR ABSTRACT:"Dynactin subunit 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DCTN1, not a curated reading list.