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CYP2D6 (Cytochrome P450 2D6) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA).
CIViC holds 1 clinical evidence item and 0 assertions across 1 variant.
In plain words · CYP2D6 (Cytochrome P450 2D6) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
CYP2D6 (Cytochrome P450 2D6) is an enzyme. The public catalogues list it as a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer.
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids.
No product in this corpus aims at CYP2D6 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
Specificity not established: no corpus medicine is aimed at it and the catalogues give it only the role biomarker; HPA finds the RNA tissue enriched, which says where the protein sits but not whether the tumour differs from normal tissue. HPA CYP2D6: RNA tissue enriched (liver 386 nTPM); high antibody staining in 1 normal tissue; highest cancer staining liver cancer (2 of 10 high). Distribution: 1 cancer family in the corpus carries a prevalence row, label threshold or catalogue link for it (Breast cancer (all types)); Open Targets associates it with 0 specific cancer types at or above 0.5. (No rule of scripts/fetch-target-specificity.ts fired.)
Sources: Human Protein Atlas CYP2D6 tissue; Open Targets ENSG00000100197 associations
First described 1988. Earliest sequence paper UniProt cites for the protein: Gonzalez F.J. et al, Genomics, 1988, "Human debrisoquine 4-hydroxylase (P450IID1): cDNA and deduced amino acid sequence and assignment of the CYP2D locus to chromosome 22". Source.
Sources: HGNC HGNC:2625 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P10635 (protein name, function text, keywords and locations (REST API)); CIViC gene CYP2D6 (1 evidence items, 0 assertions, 1 variants; diseases: Breast Cancer (GraphQL API, CC0))
A cytochrome P450 monooxygenase involved in the metabolism of fatty acids, steroids and retinoids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--haemoprotein reductase). Catalyses the epoxidation of double bonds of polyunsaturated fatty acids (PUFA). Metabolises endocannabinoid arachidonoylethanolamide (anandamide) to 20-hydroxyeicosatetraenoic acid ethanolamide (20-HETE-EA) and 8,9-, 11,12-, and 14,15-epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signalling. Catalyses the hydroxylation of carbon-hydrogen bonds. Metabolises cholesterol toward 25-hydroxycholesterol, a physiological regulator of cellular cholesterol homeostasis. Location: Endoplasmic reticulum membrane; Microsome membrane (UniProt). Locus 22q13.2 (HGNC).
RNA: tissue enriched (liver 386 nTPM), detected in some normal tissues.
RNA cancer enriched: Liver Hepatocellular Carcinoma 48 pTPM.
Human Protein Atlas version 25.1, antibody staining at reliability approved, enhanced or supported; used under CC BY-SA 3.0. Staining counts are patients per level in the atlas cohort, not population prevalence.
Query for this target: (TITLE:"CYP2D6" OR ABSTRACT:"CYP2D6" OR TITLE:"cytochrome P450 family 2 subfamily D member 6 gene/pseudogene" OR ABSTRACT:"cytochrome P450 family 2 subfamily D member 6 gene/pseudogene" OR TITLE:"Cytochrome P450 2D6" OR ABSTRACT:"Cytochrome P450 2D6" OR TITLE:"CPD6" OR ABSTRACT:"CPD6" OR TITLE:"P450-DB1" OR ABSTRACT:"P450-DB1" OR TITLE:"CYP2D" OR ABSTRACT:"CYP2D") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CYP2D6, not a curated reading list.