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CUL1 (Cullin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organises the SKP1-F-box protein and RBX1 subunits.
Open Targets scores its association with cancer at 0.53 (direct and indirect evidence; datatypes literature 0.90, affected pathway 0.83, genetic association 0.00).
In plain words · CUL1 (Cullin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
CUL1 (Cullin-1) is a gene. In the public catalogues the evidence so far is association rather than a proven role.
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription.
No product in this corpus aims at CUL1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
First described 1996. Earliest sequence paper UniProt cites for the protein: Kipreos E.T. et al, Cell, 1996, "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family". Source.
Sources: HGNC HGNC:2551 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13616 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000055130 (association with cancer (MONDO_0004992) 0.53; (GraphQL API, CC0))
Core component of multiple cullin-RING-based SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. SCF complexes and ARIH1 collaborate in tandem to mediate ubiquitination of target proteins. In the SCF complex, serves as a rigid scaffold that organises the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and exchange of the substrate recognition component is mediated by TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. Locus 7q36.1 (HGNC).
Query for this target: (TITLE:"CUL1" OR ABSTRACT:"CUL1" OR TITLE:"cullin 1" OR ABSTRACT:"cullin 1" OR TITLE:"Cullin-1" OR ABSTRACT:"Cullin-1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CUL1, not a curated reading list.