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CTSH (Pro-cathepsin H) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Important for the overall degradation of proteins in lysosomes.
Open Targets scores its association with cancer at 0.57 (direct and indirect evidence; datatypes literature 0.93, animal model 0.81, genetic association 0.70).
In plain words · CTSH (Pro-cathepsin H) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
CTSH (Pro-cathepsin H) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role.
Important for the overall degradation of proteins in lysosomes. Location: Lysosome (UniProt).
No product in this corpus aims at CTSH yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
First described 1986. Earliest sequence paper UniProt cites for the protein: Machleidt et al, 1986, "Human cathepsins B, H and L: characterization by amino acid sequences and some kinetics of inhibition by the kininogens". Source.
Sources: HGNC HGNC:2535 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt P09668 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000103811 (association with cancer (MONDO_0004992) 0.57; (GraphQL API, CC0))
Important for the overall degradation of proteins in lysosomes. Location: Lysosome (UniProt). Locus 15q25.1 (HGNC).
Query for this target: (TITLE:"CTSH" OR ABSTRACT:"CTSH" OR TITLE:"cathepsin H" OR ABSTRACT:"cathepsin H" OR TITLE:"Pro-cathepsin H" OR ABSTRACT:"Pro-cathepsin H" OR TITLE:"ACC-4" OR ABSTRACT:"ACC-4" OR TITLE:"ACC-5" OR ABSTRACT:"ACC-5" OR TITLE:"ACC4" OR ABSTRACT:"ACC4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CTSH, not a curated reading list.